Accumulating mutations
نویسندگان
چکیده
منابع مشابه
Markov Models for Accumulating Mutations
We introduce and analyze a waiting time model for the accumulation of genetic changes. The continuous time conjunctive Bayesian network is defined by a partially ordered set of mutations and by the rate of fixation of each mutation. The partial order encodes constraints on the order in which mutations can fixate in the population, shedding light on the mutational pathways underlying the evoluti...
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3 See, e.g., Brues, A. M., "The cost of evolution versus the cost of non-evolving," Evolution, 18, 379-383 (1964); Mayr, E., Animal Species and Evolution (Harvard Univ. Press, 1963). 4Feller, W., "On fitness and the cost of natural selection," to appear in Genet. Res. 5 The general case w, $ 1 is covered by our formulas if one replaces Nn by Nnw -n. The true population size is for large n given...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2019
ISSN: 1078-8956,1546-170X
DOI: 10.1038/s41591-018-0329-7